中国科学院重庆绿色智能技术研究院机构知识库

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	Discovery of novel Thymol-TPP antibiotics that eradicate MRSA persisters 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 270, 页码: 15 作者:  Tang, Ziyi;  Feng, Jizhou;  Challa, Mahesh;  Rowthu, Sankara Rao;  Xiong, Shuxin;  Zou, Cheng;  Li, Jianguo;  Verma, Chandra Shekhar;  Peng, Haibo;  He, Xiaoli;  Huang, Chao;  He, Yun 收藏  |  浏览/下载：8/0  |  提交时间：2024/07/12 Antibacterial  Thymol  Triphenylphosphonium (TPP)-conjugates  Persister
	Development of membrane-targeting TPP+-chloramphenicol conjugates to combat methicillin-resistant staphylococcus aureus (MRSA) infections 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 264, 页码: 13 作者:  Li, Tao;  He, Xiaoli;  Tao, Wenlan;  Zhang, Ruixue;  He, Qiaolin;  Gong, Hongzhi;  Liu, Ye;  Luo, Dong;  Zhang, Maojie;  Zou, Cheng;  Zhang, Shao-Lin;  He, Yun 收藏  |  浏览/下载：18/0  |  提交时间：2024/02/23 Triphenylphosphonium cation  Membrane disruption  Drug-resistance
	2,4-Diacetylphloroglucinol (DAPG) derivatives rapidly eradicate methicillin-resistant staphylococcus aureus without resistance development by disrupting membrane 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 261, 页码: 18 作者:  Zhong, Yifan;  He, Xiaoli;  Tao, Wenlan;  Feng, Jizhou;  Zhang, Ruixue;  Gong, Hongzhi;  Tang, Ziyi;  Huang, Chao;  He, Yun 收藏  |  浏览/下载：18/0  |  提交时间：2023/12/25 4-Diacetylphloroglucinol  MRSA  Antimicrobial resistance  Cell membrane  Synergy  Biofilm
	Optimization of the Natural Product Calothrixin A to Discover Novel Dual Topoisomerase I and II Inhibitors with Improved Anticancer Activity 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 11, 页码: 8040-8061 作者:  Yang, Xiaohong;  Wang, Zhi-Peng;  Xiang, Sichuan;  Wang, Daoqiang;  Zhao, Yi;  Luo, Dong;  Qiu, Yanfei;  Huang, Chao;  Guo, Jian;  Dai, Yuanwei;  Zhang, Shao-Lin;  He, Yun 收藏  |  浏览/下载：44/0  |  提交时间：2022/08/22
	Synthesis, biological evaluation and structure-activity relationship of novel dichloroacetophenones targeting pyruvate dehydrogenase kinases with potent anticancer activity 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 214, 页码: 16 作者:  Xu, Biao;  Wang, Zhi-Peng;  Liu, Qingwang;  Yang, Xiaohong;  Li, Xuemin;  Huang, Ding;  Qiu, Yanfei;  Tam, Kin Yip;  Zhang, Shao-Lin;  He, Yun 收藏  |  浏览/下载：88/0  |  提交时间：2021/05/17 Pyruvate dehydrogenase kinase  Proliferation  Cancer metabolism  Structure-activity relationship