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Development of membrane-targeting TPP+-chloramphenicol conjugates to combat methicillin-resistant staphylococcus aureus (MRSA) infections 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 264, 页码: 13
作者:  Li, Tao;  He, Xiaoli;  Tao, Wenlan;  Zhang, Ruixue;  He, Qiaolin;  Gong, Hongzhi;  Liu, Ye;  Luo, Dong;  Zhang, Maojie;  Zou, Cheng;  Zhang, Shao-Lin;  He, Yun
收藏  |  浏览/下载:7/0  |  提交时间:2024/02/23
Triphenylphosphonium cation  Membrane disruption  Drug-resistance  
Optimization of the Natural Product Calothrixin A to Discover Novel Dual Topoisomerase I and II Inhibitors with Improved Anticancer Activity 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 11, 页码: 8040-8061
作者:  Yang, Xiaohong;  Wang, Zhi-Peng;  Xiang, Sichuan;  Wang, Daoqiang;  Zhao, Yi;  Luo, Dong;  Qiu, Yanfei;  Huang, Chao;  Guo, Jian;  Dai, Yuanwei;  Zhang, Shao-Lin;  He, Yun
收藏  |  浏览/下载:38/0  |  提交时间:2022/08/22
Synthesis, biological evaluation and structure-activity relationship of novel dichloroacetophenones targeting pyruvate dehydrogenase kinases with potent anticancer activity 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 214, 页码: 16
作者:  Xu, Biao;  Wang, Zhi-Peng;  Liu, Qingwang;  Yang, Xiaohong;  Li, Xuemin;  Huang, Ding;  Qiu, Yanfei;  Tam, Kin Yip;  Zhang, Shao-Lin;  He, Yun
收藏  |  浏览/下载:76/0  |  提交时间:2021/05/17
Pyruvate dehydrogenase kinase  Proliferation  Cancer metabolism  Structure-activity relationship