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Development of membrane-targeting TPP+-chloramphenicol conjugates to combat methicillin-resistant staphylococcus aureus (MRSA) infections 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 264, 页码: 13
作者:  Li, Tao;  He, Xiaoli;  Tao, Wenlan;  Zhang, Ruixue;  He, Qiaolin;  Gong, Hongzhi;  Liu, Ye;  Luo, Dong;  Zhang, Maojie;  Zou, Cheng;  Zhang, Shao-Lin;  He, Yun
收藏  |  浏览/下载:8/0  |  提交时间:2024/02/23
Triphenylphosphonium cation  Membrane disruption  Drug-resistance  
2,4-Diacetylphloroglucinol (DAPG) derivatives rapidly eradicate methicillin-resistant staphylococcus aureus without resistance development by disrupting membrane 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 261, 页码: 18
作者:  Zhong, Yifan;  He, Xiaoli;  Tao, Wenlan;  Feng, Jizhou;  Zhang, Ruixue;  Gong, Hongzhi;  Tang, Ziyi;  Huang, Chao;  He, Yun
收藏  |  浏览/下载:9/0  |  提交时间:2023/12/25
4-Diacetylphloroglucinol  MRSA  Antimicrobial resistance  Cell membrane  Synergy  Biofilm  
Synthesis, biological evaluation and structure-activity relationship of novel dichloroacetophenones targeting pyruvate dehydrogenase kinases with potent anticancer activity 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 214, 页码: 16
作者:  Xu, Biao;  Wang, Zhi-Peng;  Liu, Qingwang;  Yang, Xiaohong;  Li, Xuemin;  Huang, Ding;  Qiu, Yanfei;  Tam, Kin Yip;  Zhang, Shao-Lin;  He, Yun
收藏  |  浏览/下载:77/0  |  提交时间:2021/05/17
Pyruvate dehydrogenase kinase  Proliferation  Cancer metabolism  Structure-activity relationship