KMS Chongqing Institute of Green and Intelligent Technology, CAS
Nanopore-based Fourth-generation DNA Sequencing Technology | |
Feng, Yanxiao1,4; Zhang, Yuechuan1,2; Ying, Cuifeng1,3; Wang, Deqiang1,4; Du, Chunlei1,4 | |
2015 | |
摘要 | Nanopore-based sequencers, as the fourth-generation DNA sequencing technology, have the potential to quickly and reliably sequence the entire human genome for less than $1000, and possibly for even less than $100. The single-molecule techniques used by this technology allow us to further study the interaction between DNA and protein, as well as between protein and protein. Nanopore analysis opens a new door to molecular biology investigation at the single-molecule scale. In this article, we have reviewed academic achievements in nanopore technology from the past as well as the latest advances, including both biological and solid-state nanopores, and discussed their recent and potential applications. |
DOI | 10.1016/j.gpb.2015.01.009 |
发表期刊 | GENOMICS PROTEOMICS & BIOINFORMATICS |
ISSN | 1672-0229 |
卷号 | 13期号:1页码:4-16 |
收录类别 | SCI |
WOS记录号 | WOS:000352110900002 |
语种 | 英语 |