KMS Chongqing Institute of Green and Intelligent Technology, CAS
| Terahertz spectroscopy of oligonucleotides in aqueous solutions | |
Tang, Mingjie ; Huang, Qing; Wei, Dongshan; Zhao, Guozhong; Chang, Tianying; Kou, Kuan; Wang, Min; Du, Chunlei; Fu, Wei-ling; Cui, Hong-Liang
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| 2015 | |
| 摘要 | A terahertz (THz) spectroscopic study is carried out to analyze DNA mutations in a label-free manner. Three newly designed liquid sample cells are considered and the best is selected as the sample carrier for THz transmission spectroscopic analyses. Discrimination based on spectral signatures of single-base mutations on single-stranded 20 nt oligonucleotides has been shown possible experimentally. The results clearly attest the ability of this promising approach for label-free analyses of single-base mutations of DNA molecules. This study has demonstrated that the THz spectroscopic technology can be considered as a potential diagnostic tool for investigating molecular reactions, such as DNA mutations. (C) 2015 Society of Photo-Optical Instrumentation Engineers (SPIE) |
| DOI | 10.1117/1.JBO.20.9.095009 |
| 发表期刊 | JOURNAL OF BIOMEDICAL OPTICS
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| ISSN | 1083-3668 |
| 卷号 | 20期号:9 |
| 通讯作者 | Cui, HL (reprint author), Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing Key Lab Multi Scale Mfg Technol, 266 Fangzheng Ave,Shuitu Hitech Ind Pk, Chongqing 400714, Peoples R China. |
| 收录类别 | SCI |
| WOS记录号 | WOS:000365128100013 |
| 语种 | 英语 |
