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	Label-free detection of anti-estrogen receptor alpha and its binding with estrogen receptor peptide alpha by terahertz spectroscopy
	Li, Mingliang1; Chang, Tianying1,2; Wei, Dongshan2; Tang, Mingjie2; Yan, Shihan2; Du, Chunlei2; Cui, Hong-Liang1,2
	2017
摘要	Terahertz (THz) spectroscopic techniques were employed to study the hydration shell formation around anti-estrogen receptor alpha (AER-alpha), an important biomarker in breast cancer diagnosis, and to detect the binding reaction between AER-alpha and estrogen receptor peptide alpha (ERP-alpha), in aqueous solutions. A remarkable nonlinear relation between THz absorption and AER-alpha concentration was demonstrated, shedding some light on the formation process of the hydration shell around AER-alpha. THz spectroscopic properties of the AER-alpha were also shown to be significantly affected by the binding with the ERP-alpha, to the extent that THz transmission and attenuation could be used to investigate the dielectric properties of antibody-antigen binding reactions.
DOI	10.1039/c6ra28754a
URL	查看原文
发表期刊	RSC ADVANCES
ISSN	2046-2069
卷号	7期号:39页码:24338-24344
通讯作者	Chang, TY (reprint author), Jilin Univ, Coll Instrumentat & Elect Engn, Changchun 130061, Jilin, Peoples R China. ; Chang, TY ; Wei, DS (reprint author), Chinese Acad Sci, Chongqing Key Lab Multiscale Mfg Technol, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China.
收录类别	SCI
WOS记录号	WOS:000401525500052
语种	英语