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Carboxylated Nanodiamond: Aggregation Properties in Aqueous Dispersion System and Application in Living Cell Fluorescence Imaging
Lei, Ying1,2,4; Zheng, Mei-Ling1,2; Zhao, Zhen-Sheng1,2; Duan, Xuan-Ming1,2,3
2016-03-01
摘要Nanodiamond, which has a lattice defect, the energy band gap and good biocompatibility, is an ideal inorganic fluorescent imaging material for cells. However, the nanodiamond aggregation is not exactly suitable for cells' endocytosis if the size is too small or too big. Therefore, it has a profound meaning to modify the surface of nanodiamond and control the dispersion of nanodiamond aggregate. In this study, the surface of the detonated nanodiamond is modified into carboxylated nanodiamond by using the method of mixed acid oxidation. Then, the nanodiamond aggregates' dispersion in water is regulated by adjusting the pH, which is first discussed as a factor influencing the size of nanodiamond aggregation. This process further induces the corresponding change of the electrostatic force between nanoparticles, improves its applicability in the field of living cell fluorescence imaging.
关键词Nanodiamond Surface Modification pH Aggregate Fluorescence Imaging
DOI10.1166/jnn.2016.10932
发表期刊JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
ISSN1533-4880
卷号16期号:3页码:2319-2324
通讯作者Zheng, ML ; Duan, XM (reprint author), Chinese Acad Sci, Tech Inst Phys & Chem, Lab Organ NanoPhoton, Beijing 100190, Peoples R China. ; Zheng, ML ; Duan, XM (reprint author), Chinese Acad Sci, Tech Inst Phys & Chem, Key Lab Funct Crystals & Laser Technol, Beijing 100190, Peoples R China. ; Duan, XM (reprint author), Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Shuitu Technol Dev Zone, Chongqing 400714, Peoples R China.
收录类别SCI
WOS记录号WOS:000374153800028
语种英语