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3D hydrogels with high resolution fabricated by two-photon polymerization with sensitive water soluble initiators
Xing, Jinfeng1; Liu, Ling1; Song, Xiaoyan1; Zhao, Yuanyuan2,3; Zhang, Ling1; Dong, Xianzi2,3; Jin, Feng2,3; Zheng, Meiling2,3; Duan, Xuanming2,3,4
2015
摘要Hydrogels with precise 3D configuration (3D hydrogels) are crucial for biomedical applications such as tissue engineering and drug delivery, which require the improvement of the spatial resolution on both the microscopic and the nanometric scale. In this study, a water soluble two-photon polymerization (TPP) initiator (WI) with high initiating efficiency was prepared by using a poloxamer (PF127) to encapsulate 2,7-bis(2-(4-pentaneoxy-phenyl)-vinyl) anthraquinone via a hydrophilic-hydrophobic assembly. The threshold energy for WI was 6.29 mW at a linear scanning speed of 10 mu m s(-1), which was much lower than those reported previously. A lateral spatial resolution of 92 nm was achieved as the resolution breakthrough of 3D hydrogels. Finally, the microstructure with high accuracy simulating the morphology of adenovirus was fabricated at the laser power close to the threshold energy of TPP, further demonstrating the ultrahigh resolution of 3D hydrogels.
DOI10.1039/c5tb01545f
发表期刊JOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-750X
卷号3期号:43页码:8486-8491
通讯作者Xing, JF (reprint author), Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China.
收录类别SCI
WOS记录号WOS:000364103100007
语种英语