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Direct oxidative cyanation of tertiary amines promoted by in situ generated hypervalent iodine(III)-CN intermediate
Shen, Hang1; Zhang, Xiaohui1; Liu, Qing1; Pan, Jing1; Hu, Wen1; Xiong, Yan1,2; Zhu, Xiangming3
2015-10-07
摘要

An environmentally benign and metal-free cyanation method of tertiary amines oxidated by hypervalent iodine(III) intermediate generated in situ from PIFA (or DIB) and TMSCN has been developed. A variety of substituent groups on amines are tolerated to the oxidation of alpha-C-H bond to form C-C bond in the absence of metal catalysts with yields of up to 74%. (C) 2015 Elsevier Ltd. All rights reserved.

关键词Alpha-aminonitriles Cyanation n,N-dialkylanilines Hypervalent Iodine Tmscn
DOI10.1016/j.tetlet.2015.08.058
发表期刊TETRAHEDRON LETTERS
ISSN0040-4039
卷号56期号:41页码:5628-5631
收录类别SCI
WOS记录号WOS:000361926100034
语种英语