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Engineered Cell Membrane-Coated Nanoparticles: New Strategies in Glioma Targeted Therapy and Immune Modulation
Ma, Yilei1,2,3; Yi, Jia1,2; Ruan, Jing1,2; Ma, Jiahui1,2; Yang, Qinsi4; Zhang, Kun5; Zhang, Maolan6; Zeng, Guoming6; Jin, Libo1,2,3; Huang, Xiaobei7
2024-05-02
摘要Gliomas, the most prevalent primary brain tumors, pose considerable challenges due to their heterogeneity, intricate tumor microenvironment (TME), and blood-brain barrier (BBB), which restrict the effectiveness of traditional treatments like surgery and chemotherapy. This review provides an overview of engineered cell membrane technologies in glioma therapy, with a specific emphasis on targeted drug delivery and modulation of the immune microenvironment. This study investigates the progress in engineered cell membranes, encompassing physical, chemical, and genetic alterations, to improve drug delivery across the BBB and effectively target gliomas. The examination focuses on the interaction of engineered cell membrane-coated nanoparticles (ECM-NPs) with the TME in gliomas, emphasizing their potential to modulate glioma cell behavior and TME to enhance therapeutic efficacy. The review further explores the involvement of ECM-NPs in immunomodulation techniques, highlighting their impact on immune reactions. While facing obstacles related to membrane stability and manufacturing scalability, the review outlines forthcoming research directions focused on enhancing membrane performance. This review underscores the promise of ECM-NPs in surpassing conventional therapeutic constraints, proposing novel approaches for efficacious glioma treatment. Engineered cell membrane-coated nanoparticles (ECM-NPs) have enhanced drug delivery across the blood-brain barrier to more effectively target glioma cells. The interaction of these ECM-NPs with the tumor microenvironment (TME) in the glioma and their effect on the immune response are highlighted, showing their potential to modify glioma cell behavior and modulate the TME to improve therapeutic outcomes. image
关键词engineered cell membrane-coated nanoparticles glioma immunomodulation strategies targeted drug delivery tumor microenvironment
DOI10.1002/adhm.202400514
发表期刊ADVANCED HEALTHCARE MATERIALS
ISSN2192-2640
页码17
通讯作者Li, Jianshu(jianshu_li@scu.edu.cn) ; Yang, Haifeng(yanghaifeng@cqu.edu.cn) ; Wu, Wei(david2015@cqu.edu.cn) ; Sun, Da(sunday@wzu.edu.cn)
收录类别SCI
WOS记录号WOS:001216832900001
语种英语