中国科学院重庆绿色智能技术研究院机构知识库

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	Developmental Toxicity of PEDOT:PSS in Zebrafish: Effects on Morphology, Cardiac Function, and Intestinal Health
	Yang, Guan1,2,3; Gou, Dongzhi3; Bu, Ling-Kang2,3; Wei, Xing-Yi1,2,3; Hu, Huan1,2,3; Huo, Wen-Bo2,3; Sultan, Marriya2,3; Pei, De-Sheng3
	2024-02-01
摘要	Poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) is a conductive polymer commonly used in various technological applications. However, its impact on aquatic ecosystems remains largely unexplored. In this study, we investigated the toxicity effects of PEDOT:PSS on zebrafish. We first determined the lethal concentration (LC50) of PEDOT:PSS in zebrafish and then exposed AB-type zebrafish embryos to different concentrations of PEDOT:PSS for 120 h. Our investigation elucidated the toxicity effects of zebrafish development, including morphological assessments, heart rate measurements, behavioral analysis, transcriptome profiling, and histopathological analysis. We discovered that PEDOT:PSS exhibited detrimental effects on the early developmental stages of zebrafish, exacerbating the oxidative stress level, suppressing zebrafish activity, impairing cardiac development, and causing intestinal cell damage. This study adds a new dimension to the developmental toxicity of PEDOT:PSS in zebrafish. Our findings contribute to our understanding of the ecological repercussions of PEDOT:PSS and highlight the importance of responsible development and application of novel materials in our rapidly evolving technological landscape.
关键词	developmental toxicity histopathological image analysis oxidative stress transcriptomic analysis zebrafish
DOI	10.3390/toxics12020150
发表期刊	TOXICS
卷号	12期号:2页码:14
通讯作者	Pei, De-Sheng(peids@cqmu.edu.cn)
收录类别	SCI
WOS记录号	WOS:001172174400001
语种	en