KMS Chongqing Institute of Green and Intelligent Technology, CAS
| Low-noise and high-speed trans-impedance amplifier for nanopore sensor | |
Fang, Shaoxi1,2 ; Yin, Bohua1,3; Xie, Wanyi1,2; He, Shixuan1,2; Liang, Liyuan1,2; Tang, Peng1,2; Tian, Rong1,2; Weng, Ting1,2; Yuan, Jiahu1,2; Wang, Deqiang1,2,3
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| 2023-07-01 | |
| 摘要 | The small current detection circuit is the core component of the accurate detection of the nanopore sensor. In this paper, a compact, low-noise, and high-speed trans-impedance amplifier is built for the nanopore detection system. The amplifier consists of two amplification stages. The first stage performs low-noise trans-impedance amplification by using ADA4530-1, which is a high-performance FET operational amplifier, and a high-ohm feedback resistor of 1 GO. The high pass shelf filter in the second stage recovers the higher frequency above the 3 dB cutoff in the first stage to extend the maximum bandwidth up to 50 kHz. The amplifier shows a low noise below sub-2 pA rms when tuned to have a bandwidth of around 5 kHz. It also guarantees a stable frequency response in the nanopore sensor. |
| DOI | 10.1063/5.0155192 |
| 发表期刊 | REVIEW OF SCIENTIFIC INSTRUMENTS
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| ISSN | 0034-6748 |
| 卷号 | 94期号:7页码:6 |
| 通讯作者 | Wang, Deqiang(dqwang@cigit.ac.cn) |
| 收录类别 | SCI |
| WOS记录号 | WOS:001029362300001 |
| 语种 | 英语 |
