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Potential roles for lncRNA Mirg/Foxp1 in an ARHL model created using C57BL/6J mice
Luo, Xiaoqin1,2,3,4; Hu, Yaqin1,2,3,4; Zhou, Xiaoqing1,2,3,4; Zhang, Chanyuan1,2,3,4; Feng, Menglong1,2,3,4; Yang, Ting1,2,3,4; Yuan, Wei1,2,3,4
2023-10-01
摘要Age-related hearing loss (ARHL) is associated with hair cell apoptosis, but the underlying mechanism of hair cell apoptosis remains unclear. Here, we investigated the expression profiles of long noncoding RNAs (lncRNAs) and mRNAs in an ARHL model created with C57BL/6 J mice using RNA sequencing and found that the expression of several lncRNAs was significantly correlated with apoptosis-associated mRNAs in the cochlear tissues of old mice compared to young mice. We found that lncRNA Mirg was upregulated in the cochlear tissues of old mice compared to young mice and its overexpression promoted apoptosis in House Ear Institute-Organ of Corti 1 (HEI-OC1). H2O2-induced oxidative stress increased HEI-OC1 cell apoptosis by upregulating lncRNA Mirg. Further-more, the expression of lncRNA Mirg and Foxp1 showed the highest correlation coefficient in the cochlear tissues of old mice, and lncRNA Mirg promoted HEI-OC1 cell apoptosis by increasing Foxp1 expression. In conclusion, our findings suggest that lncRNA Mirg expression correlates with cell apoptosis-associated mRNAs in the ARHL model created using C57BL/6 J mice and that oxidative stress-induced lncRNA Mirg promotes HEI-OC1 cell apoptosis by increasing Foxp1 expression. These data suggest the potential therapeutic significance of targeting lncRNA Mirg/Foxp1 signaling in ARHL.
关键词LncRNA Mirg Cochlear hair cell Foxp1 Apoptosis Age-related hearing loss
DOI10.1016/j.heares.2023.108859
发表期刊HEARING RESEARCH
ISSN0378-5955
卷号438页码:8
通讯作者Yuan, Wei(yuanwei@ucas.ac.cn)
收录类别SCI
WOS记录号WOS:001059216800001
语种英语