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Imaging-based assessment of body composition in patients with Crohn's disease: a systematic review
Tang, Wuli1,2,3,4; Xie, Gang4; Wang, Danni4; Li, Ting4; Ren, Yitao4; Li, Junlin4; Deng, Jiaxing4; Li, Kang1,4
2023-05-12
摘要Background and aimsBody composition changes in patients with Crohn's disease (CD) have received increasing attention in recent years. This review aims to describe the changes in body composition in patients with CD on imaging and to analyze and summarize the prognostic value of body composition.MethodsWe systematically searched Web of Science, PubMed, Embase, Cochrane Library, and Medline via OVID for literature published before November 2022, and two researchers independently evaluated the quality of the retrieved literature.ResultsA total of 39 publications (32 cohort studies and 7 cross-sectional studies) involving 4219 patients with CD were retrieved. Imaging methods for body composition assessment, including dual-energy X-ray absorptiometry (DXA), computed tomography (CT) and magnetic resonance imaging (MRI), were included in this review. The study found that patients with CD typically have more visceral adipose tissue and less skeletal muscle mass, and the prevalence of sarcopenia and visceral obesity was significantly different in different studies (sarcopenia: 16-100%; visceral obesity: 5.3-30.5%). Available studies suggest that changes in the body composition of CD patients are significantly related to inflammatory status, disease behavior, poor outcomes, and drug efficacy.ConclusionAltered body composition can be a significant predictor of poor outcomes for CD patients. Therefore, the body composition of CD patients may serve as a potential therapeutic target to help optimize disease management strategies in clinical practice.
关键词Crohn's disease Body composition Nutritional status Visceral fat Skeletal muscle tissue Imaging method
DOI10.1007/s00384-023-04413-w
发表期刊INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
ISSN0179-1958
卷号38期号:1页码:12
通讯作者Li, Kang(likangdoctor@126.com)
收录类别SCI
WOS记录号WOS:000986352700002
语种英语