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Multifunctional hydrogels for wound dressings using xanthan gum and polyacrylamide
Tang, Song1; Gong, Zhoujie1; Wang, Zefan2; Gao, Xia3,4; Zhang, Xiaonan1,5
2022-09-30
摘要Developing advanced dressings that integrate multiple functions is one of the major challenges in current clinical wound treatment. In this study, Xanthan gum (XG) and polyacrylamide (PAAm) materials were used to prepare hydrogel dressings by one-pot method. With the combination of the PAAm network and the XG network, the PAAm-XG hydrogels showed the tensile strength of 0.36 MPa and the stretchability as large as 2078 %. The prepared PAAm-XG hydrogels had excellent water uptake efficiency with the swelling ratio of 1200 %. Besides, the developed dressings possessed outstanding biocompatibility, universal adhesion and self-healing ability. More importantly, the PAAm-XG hydrogels can be successfully loaded with Cefixime and human recombinant epidermal growth factor, and these loaded hydrogels released these bioactive molecules in sustained ways. As a result, both E. coli and S. aureus bacteria were inactivated after contacting with the Cefixime-loaded hydrogels for 24 h. Furthermore, in vivo data demonstrated that the PAAm-XG hydrogel dressings significantly accelerated the wound healing in a mouse model. All of these indicate that the multifunctional PAAm-XG hydrogels are promising candidates for wound treatment.
关键词Hydrogel dressings Xanthan gum Mechanical properties Wound healing Release behavior
DOI10.1016/j.ijbiomac.2022.07.181
发表期刊INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN0141-8130
卷号217页码:944-955
通讯作者Gao, Xia(gaoxia@cigit.ac.cn) ; Zhang, Xiaonan(500133@hospital.cqmu.edu.cn)
收录类别SCI
WOS记录号WOS:000878627200008
语种英语