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Morphological Changes of Melanoma Cells Induced by Pulsed Terahertz Radiation
Zhou, Huan1,2,3; Peng, Xiao-Yu2; Gou, Yangjiuzhou2; Pei, Desheng4; Zhang, Xi5; Zhong, Julia Li1
2022-10-05
摘要Strong terahertz (THz) waves can induce a series of biological effects including morphology changes in living cells. Morphology change is an intuitive indicator of biological effects and would be helpful for understanding these effects. Up to now, only several cells' morphology changes induced by THz waves have been investigated. Related reports are not found for tumor or cancer cells. We preliminary investigated in vitro the effects of melanoma cells exposed to our strong broadband pulsed THz source (500 mW/cm(2), 1 kHz repetition rate). After 3 h irradiation, we observed obvious morphological changes on most of these cancer cells with an increase of 4 degrees in temperature. Under the same conditions but suppressing the increase of temperature by reducing the repetition rate of THz source to 100 Hz, morphological changes were not observed. Those morphological changes in melanoma cells exposed to THz source with an intensity of 500 mW/cm(2) and a repetition rate of 1 kHz could be attributed mainly to the thermal effects caused by THz waves. The recovery of morphology of the irradiated melanoma cells as well as the similar apoptosis rate of the THz-irradiated melanoma cells and that of the controls indicates that both the thermal and nonthermal effects would not induce fatal and permanent damages to the melanoma cells under the condition of current parameters of our THz source.
关键词THz radiation Melanoma cells Morphological change Thermal effect
DOI10.1007/s10762-022-00880-4
发表期刊JOURNAL OF INFRARED MILLIMETER AND TERAHERTZ WAVES
ISSN1866-6892
页码14
通讯作者Peng, Xiao-Yu(xypeng@cigit.ac.cn)
收录类别SCI
WOS记录号WOS:000864046600001
语种英语