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Cyclic poly(beta-amino ester)s with enhanced gene transfection activity synthesized through intra-molecular cyclization
Wang, Chenfei1; Huang, Xiaobei2; Sun, Litao1; Li, Qiuxia1; Li, Zhili1; Yong, Haiyang1; Che, Delu3; Yan, Cong3; Geng, Songmei3; Wang, Wenxin4
2022-01-12
摘要Topological structure plays a critical role in gene delivery of cationic polymers. Cyclic poly(beta-amino ester)s (CPAEs) are successfully synthesized via sequential Michael addition and free radical initiating ring-closure reaction. The CPAEs exhibit superior gene transfection efficiency and safety profile compared to their linear counterparts.
DOI10.1039/d1cc06480k
发表期刊CHEMICAL COMMUNICATIONS
ISSN1359-7345
页码4
通讯作者Geng, Songmei(gsm312@yahoo.com) ; Zhou, Dezhong(dezhong.zhou@xjtu.edu.cn)
收录类别SCI
WOS记录号WOS:000743619000001
语种英语