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Single nucleotide discrimination with sub-two nanometer monolayer graphene pore
Zhang, Zi-Yin1; Cui, Hong-Liang1,2; Huang, De-Ping1; Wang, De-Qiang1
2021-12-15
摘要The effective sensing area is the key point of solid-state nanopore single-molecule detection, which is determined by the diameter of the hole and the thickness of the membrane. High spatial resolution can be achieved by using single-atom thickness two-dimensional materials, such as single-layer graphene and molybdenum disulfide. Helium ion beam microscopy provides an effective technique for manufacturing small-sized nanopores. Here, we show that the precise fabrication of sub-2 nanometer nanopores has been successfully achieved on a single-layer graphene film, which provides the best spatial resolution in room-temperature ionic liquid-assisted singlemolecule detection. Many graphene nanopores of different sizes have been fabricated, with a minimum pore diameter of 1.4 nm. The application of these graphene nanopores manufactured by HIM shows that single-layer graphene nanopores can distinguish different homopolymer single-stranded DNA lengths and types, and can even identify four single nucleotides.
关键词Monolayer graphene Solid-state nanopore Helium ion milling Single nucleotide
DOI10.1016/j.snb.2021.130792
发表期刊SENSORS AND ACTUATORS B-CHEMICAL
卷号349页码:10
通讯作者Cui, Hong-Liang(hcui@jlu.edu.cn) ; Wang, De-Qiang(dqwang@cigit.ac.cn)
收录类别SCI
WOS记录号WOS:000707315100002
语种英语