KMS Chongqing Institute of Green and Intelligent Technology, CAS
Femtosecond laser-induced periodic grooves and nanopore clusters make a synergistic effect on osteogenic differentiation | |
Xie, Haiqiong1,2; Zhang, Chenke1; Wang, Rui2; Tang, Hong1; Mu, Miduo1; Li, Huaisheng1; Guo, Yupeng1; Yang, Liang3; Tang, Kanglai1 | |
2021-12-01 | |
摘要 | Polyether-ether-ketone (PEEK) materials have good biocompatibility, excellent corrosion resistance, chemical stability and an elastic modulus close to that of natural bone. However, due to its biological inertness, PEEK may affect osteogenic differentiation and leads to osseointegration failure, though PEEK is expected to improve osseointegration. In this work, by changing the power of femtosecond laser, micro-grooves are made on the PEEK surface. As observed by scanning electron microscopy, the trench has a periodic structure, the micro shape is neat, and the trench is also covered with nanometer-level pore clusters. In the in vitro culture experiments, through the proliferation experiment of mouse bone marrow mesenchymalstem cells (mBMSCs), cell viability analysis and alkaline phosphatase activity analysis, it is proven that after femtosecond laser treatment of the PEEK surface, the micro-grooves on the surface and the nanopore clusters due to laser energy ablation can produce a synergistic effect, enhancing the osteogenic differentiation ability of cells, and improving the bone integration ability of PEEK materials. |
关键词 | Femtosecond laser Osteogenic differentiation Nanopore cluster Synergy Periodic groove |
DOI | 10.1016/j.colsurfb.2021.112021 |
发表期刊 | COLLOIDS AND SURFACES B-BIOINTERFACES |
ISSN | 0927-7765 |
卷号 | 208页码:9 |
通讯作者 | Yang, Liang(yangl@cigit.ac.cn) ; Tang, Kanglai(tangkanglai@hotmail.com) |
收录类别 | SCI |
WOS记录号 | WOS:000702868500008 |
语种 | 英语 |