中国科学院重庆绿色智能技术研究院机构知识库

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	Study on an artificial phenomenon observed in terahertz biological imaging
	Yang, Zhongbo1,2,3; Zhang, Muyang4; Li, Dandan1,2; Chen, Ligang1,2; Fu, Ailing5; Liang, Yanmei4; Wang, Huabin1,2,3
	2021-06-01
摘要	Terahertz (THz) wave-based imaging of biological samples is an emerging but promising field. In the present work, we report an artificial phenomenon observed in imaging melanoma slices, which can lead to mistakenly interpretation of the experimental results. It was observed that a structure similar to but smaller than the sample contour appeared inside the melanoma slice image. The underlying mechanism of this phenomenon was then investigated both experimentally and theoretically. By imaging a regular standard sample (vinyl coverslip) with a THz time domain spectroscopy (THz-TDS) system and reconstructing its images at 0.8 and 1.2 THz, we can clearly observe the afore-mentioned artifacts. The experimental results are highly consistent with the simulations based on the Fresnel-Kirchhoff diffraction theory in which possible optical aberrations were incorporated. It can be concluded that this artifact was caused by the frequency-dependent diffraction of the sample edge. The work demonstrated here is essential for correct interpretation of the images obtained by the THz-TDS technique. (c) 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
DOI	10.1364/BOE.424445
发表期刊	BIOMEDICAL OPTICS EXPRESS
ISSN	2156-7085
卷号	12期号:6页码:3133-3141
通讯作者	Liang, Yanmei(ymliang@nankai.edu.cn)
收录类别	SCI
WOS记录号	WOS:000656913900006
语种	英语