中国科学院重庆绿色智能技术研究院机构知识库

QQ客服 官方微博 反馈留言

	Chronic exposure to PPCPs mixture at environmentally relevant concentrations (ERCs) altered carbohydrate and lipid metabolism through gut and liver toxicity in zebrafish
	Hamid, Naima1,2; Junaid, Muhammad1; Wang, Yan1,2; Pu, Shi-Ya1,2; Jia, Pan-Pan1; Pei, De-Sheng1,2,3
	2021-03-15
摘要	Pharmaceuticals and personal care products (PPCPs) have been widely distributed and posed ecotoxicological risks in the aquatic environment. This study aims to evaluate the toxic effects after chronic exposure to PPCPs mixture at the environment relevant concentrations (ERCs). Our results indicated that PPCPs induced serious metabolic effects by disturbing the carbohydrate and lipid metabolism pathways. Chronic exposure caused a significant reduction in the hepatosomatic index (HSI), the gut weight ratios, and histological alterations in liver and gut tissues. Further, exposure to the combined PPCPs disrupted the carbohydrate metabolism via significant upregulation of hk1, gk, pck1, and insr genes. The lipid metabolism was affected with higher ppars expression levels that increased the fatty acid beta-oxidation and ultimately decreased the lipidogenesis. Moreover, the altered responses of the insulin growth factor (IGF) pathway more in male gut tissue than that of female revealed sex-dependent disturbance in the gut homeostasis induced by PPCPs mixture. In conclusion, chronic exposure to PPCPs mixtures at ERCs can induce developmental effects and metabolic dysfunction in both male and female fish. The consumption and environmental disposal of these PPCPs should be regulated to ensure ecological health and environmental safety. (C) 2021 Elsevier Ltd. All rights reserved.
关键词	Hepatotoxicity Gut homeostasis Chronic exposure Lipid metabolism Zebrafish
DOI	10.1016/j.envpol.2021.116494
发表期刊	ENVIRONMENTAL POLLUTION
ISSN	0269-7491
卷号	273页码:10
通讯作者	Pei, De-Sheng(peids@cigit.ac.cn)
收录类别	SCI
WOS记录号	WOS:000625376600073
语种	英语