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Role of manganese superoxide dismutase (Mn-SOD) against Cr(III)-induced toxicity in bacteria
Niu, Aping1,2; Bian, Wan-Ping1; Feng, Shuang-Long1; Pu, Shi-Ya1,4; Wei, Xing-Yi1,5; Yang, Yi-Fan1,3; Song, Li-Yan1; Pei, De-Sheng1,3,4
2021-02-05
摘要The toxicity of Cr(VI) was widely investigated, but the defense mechanism against Cr(III) in bacteria are seldom reported. Here, we found that Cr(III) inhibited bacterial growth and induced reactive oxygen species (ROS). After exposure to Cr(III), loss of sodA not only led to the excessive generation of ROS, but also enhanced the level of lipid peroxidation and reduced the GSH level, indicating that the deficiency of Mn-SOD decreased the bacterial resistance ability against Cr(III). The adverse effects of oxidative stress caused by Cr(III) could be recovered by the rescue of Mn-SOD in the sodA-deficient strain. Besides the oxidative stress, Cr(III) could cause the bacterial morphology variation, which was distinct between the wild-type and the sodA-deficient strains due to the differential expressions of Z-ring division genes. Moreover, Mn-SOD might prevent Cr(III) from oxidation on the bacterial surface by combining with Cr(III). Taken together, our results indicated that the Mn-SOD played a vital role in regulating the stress resistance, expression of cell division-related genes, bacterial morphology, and chemistry valence state of Cr. Our findings firstly provided a more in-depth understanding of Cr(III) toxicity and bacterial defense mechanism against Cr(III).
关键词Oxidative stress Mn-SOD Morphology variation Cell division Cr species
DOI10.1016/j.jhazmat.2020.123604
发表期刊JOURNAL OF HAZARDOUS MATERIALS
ISSN0304-3894
卷号403页码:10
通讯作者Pei, De-Sheng(peids@cigit.ac.cn)
收录类别SCI
WOS记录号WOS:000596474900003
语种英语