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Role of Mitochondrial Dysfunction in the Pathology of Amyloid-beta
Huang, Zhenting1,2; Yan, Qian1,2,4; Wang, Yangyang1,2; Zou, Qian1,2; Li, Jing1,2; Liu, Zhou3; Cai, Zhiyou1,2
2020
摘要Mitochondrial dysfunction has been widely reported in several neurodegenerative disorders, including in the brains of patients with Alzheimer's disease (AD), Parkinson's disease, and Huntington disease. An increasing number of studies have implicated altered glucose and energy metabolism in patients with AD. There is compelling evidence of abnormalities in some of the key mitochondrial enzymes involved in glucose metabolism, including the pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase complexes, which play a great significance role in the pathogenesis of AD. Changes in some of the enzyme activities of the mitochondria found in AD have been linked with the pathology of amyloid-beta (A beta). This review highlights the role of mitochondrial function in the production and clearance of A beta and how the pathology of A beta leads to a decrease in energy metabolism by affecting mitochondrial function.
关键词Alzheimer's disease amyloid-beta dysfunction mitochondria pathology
DOI10.3233/JAD-200519
发表期刊JOURNAL OF ALZHEIMERS DISEASE
ISSN1387-2877
卷号78期号:2页码:505-514
通讯作者Liu, Zhou(liuzhou@gdmu.edu.cn) ; Cai, Zhiyou(caizhiyou@ucas.ac.cn)
收录类别SCI
WOS记录号WOS:000592248100002
语种英语