中国科学院重庆绿色智能技术研究院机构知识库

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	Bench-stable imine surrogates for the one-pot and catalytic asymmetric synthesis of alpha-amino esters/ketones
	Xu, Huacheng1; Nazli, Adila1; Zou, Cheng1; Wang, Zhi-Peng2; He, Yun1
	2020-11-25
摘要	N,O-Bis(tert-butoxycarbonyl)hydroxylamines are readily accessible as imine surrogates, which are bench stable and could quantitatively generate the corresponding imines for in situ applications. An unpresented catalytic asymmetric method for the synthesis of alpha-amino esters and ketones from novel imine surrogates, N,O-bis(tert-butoxycarbonyl)hydroxylamines, as well as its preliminary mechanistic studies are reported. A variety of optically enriched products were obtained in excellent yields and enantioselectivities (up to 99% yield and >99% ee).
DOI	10.1039/d0cc06055k
发表期刊	CHEMICAL COMMUNICATIONS
ISSN	1359-7345
卷号	56期号:91页码:14243-14246
通讯作者	Wang, Zhi-Peng(wangzhipeng@cigit.ac.cn) ; He, Yun(yun.he@cqu.edu.cn)
收录类别	SCI
WOS记录号	WOS:000590124000020
语种	英语