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Applications of Photo-Responsive Molecules in Nanopore-based Devices
Tang Jing1,2; Wang Sen1,2; Wu Ji1,2; Liang Li-Yuan1; Wang Liang1; Wang De-Qiang1
2020-11-01
摘要In biochemistry, exploring the conformation, response to external environment and interaction rules of biomacromolecules and small molecules is crucial to understanding the correlation of structures and properties among organic matters. However, it is a challenge for the traditional techniques to observe the conformation heterogeneity and interpret the interaction mechanism of the biomolecules in living cells. As the emerged third generation single-molecule gene sequencing technology, nanopore can monitor the conformation change of the molecules in situ and therefore demonstrates good applications in single-molecule sensing and nucleic acid and protein sequencing. To further improve the detection resolution and precision, the combined photoelectric detection can achieve higher accuracy via introducing optical-responsive molecules. In view of the extensive applications and development status of nanopore technique in single-molecule conformation resolution, this paper summarizes the research progress of the nanopore devices and the design and applications of some typical photo-responsive molecules in nanopore sensing, including azobenzenes and their derivatives, spiropyrane and diarylethene. Light regulation is a simple and effective approach monitoring the molecular structures, and further integration with nanopore devices exhibits great potential in single-molecule detection meanwhile sheds light on the design and applications of multi-responsive nano-devices.
关键词Nanopores Light regulation Biosensors Photo-responsive molecules Structure switch Review
DOI10.19756/j.issn.0253-3820.201247
发表期刊CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
ISSN0253-3820
卷号48期号:11页码:1458-1466
通讯作者Liang Li-Yuan(liangliyuan@cigit.ac.cn) ; Wang De-Qiang(dqwang@cigit.ac.cn)
收录类别SCI
WOS记录号WOS:000590139800004
语种英语