中文版 | English
CSpace
Photodynamic Nanophotosensitizers: Promising Materials for Tumor Theranostics
Keerthiga, Rajendiran1; Zhao, Zizhen1; Pei, Desheng2; Fu, Ailing1
2020-10-01
摘要Photodynamic theranostics/therapy (PDT) is a potential strategy for selectively imaging malignant sites and treating cancer via a non-invasive therapeutic method. Photosensitizers, the crucial components of PDT, enable colocalization of photons and light, and photon/light therapy in the therapeutic window of 400-900 nm exhibits photocytotoxicity to tumor cells. Due to their high biostability and photocytotoxicity, nanophotosensitizers (NPSs) are of much interest for malignant tumor theranostics at present. NPS-activated photons transfer energy through the absorption of a photon and convert molecular oxygen to the singlet reactive oxygen species, which leads to apoptosis and necrosis. Moreover, NPSs modified by polymers, including PLGA, PEG-PLA, PDLLA, PVCL-g-PLA, and P(VCL-co-VIM)-g-PLA, exhibit excellent biocompatibility, and a tumor-targeting molecule linked on the nanoparticle surface can precisely deliver NPSs into the tumor region. The development of NPSs will accelerate the progress in tumor theranostics through the photon/light pathway.
关键词photodynamic therapy photosensitizer oncological therapeutics nanocarriers reactive oxygen species upconversion nanoparticles
DOI10.1021/acsbiomaterials.0c01058
发表期刊ACS BIOMATERIALS SCIENCE & ENGINEERING
ISSN2373-9878
卷号6期号:10页码:5474-5485
通讯作者Pei, Desheng(peids@cigit.ac.cn) ; Fu, Ailing(fal@swu.edu.cn)
收录类别SCI
WOS记录号WOS:000580903800007
语种英语