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	Pillar[5]arene-based, dual pH and enzyme responsive supramolecular vesicles for targeted antibiotic delivery against intracellular MRSA
	Peng, Haibo1; Xie, Beibei1; Yang, Xiaohong2; Dai, Jiaojiao1; Wei, Guoxing1; He, Yun1
	2020-07-25
摘要	A rationally designed mannosylated amphiphilic pillar[5]arene (Man@AP5) self-assembles into supramolecular vesicles with encapsulated vancomycin (Man@AP5-Van), which target macrophages, respond to both acid and cathepsin B, and release vancomycin (Van) rapidly inside macrophages. Man@AP5-Van significantly increases the intracellular concentration of Van, enhancing its antibacterial efficacy against intracellular MRSA.
DOI	10.1039/d0cc02522d
发表期刊	CHEMICAL COMMUNICATIONS
ISSN	1359-7345
卷号	56期号:58页码:8115-8118
通讯作者	He, Yun(yun.he@cqu.edu.cn)
收录类别	SCI
WOS记录号	WOS:000550563800023
语种	英语