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Protein-Based 3D Microstructures with Controllable Morphology and pH-Responsive Properties
Wei, Shuxin1; Liu, Jie2,3; Zhao, Yuanyuan4; Zhang, Tingbin1; Zheng, Meiling2,3,5; Jin, Feng2,3; Dong, Xianzi2,3; Xing, Jinfeng1; Duan, Xuanming4
2017-12-06
摘要The microtechnology of controlling stimuli responsive biomaterials at micrometer scale is crucial for biomedical applications. Here, we report bovine serum albumin (BSA)-based three-dimensional (3D) microstructures with tunable surface morphology and pH-responsive properties via two-photon polymerization microfabrication technology. The laser processing parameters, including laser power, scanning speed, and layer distance, are optimized for the fabrication of well-defined 3D BSA microstructures. The tunable morphology of BSA microstructures and a wide range of pH response corresponding to the swelling ratio of 1.08-2.71 have been achieved. The swelling behavior of the microstructures can be strongly influenced by the concentration of BSA precursor, which has been illustrated by a reasonable mechanism. A panda face-shaped BSA microrelief with reversible pH responsive properties is fabricated and exhibits unique "facial expression" variations in pH cycle. We further design a mesh sieve shaped microstructure as a functional device for promising microparticle separation. The pore sizes of microstructures can be tuned by changing the pH values. Therefore, such protein -based microstructures with controllable morphology and pH responsive properties have potential applications especially in biomedicine and biosensors.
关键词two-photon polymerization bovine serum albumin 3D microstructure morphology pH response
DOI10.1021/acsami.7b14915
发表期刊ACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
卷号9期号:48页码:42247-42257
收录类别SCI
WOS记录号WOS:000417669300066
语种英语